Sibutramine hcl 20mg base powder
2.Appearance:White crystalline powder
3.Specification:98%
4.CAS No.:C17H26ClN
5.Molecular Formula:C22H30N6O4S
6.Molecular Weight:474.58
7.Payment Method:T/T Alipay
8.Certificates: FDA,Organic,Kosher, ISO, HALAL, HACCP, GMP
9.Transport Package:1kg Aluminum Foil Bag/25kg Drum
10.Factory situation:One Factories & Three production lines.GMP standard workshop & two independent laboratories.
11.Storage method:Dry and cool place
12.MOQ:1KG
13.Service: powder"
Professional manufacturer of Sibutramine hcl 20mg base powder
Guangzhou Jianbei Biotechnology Co., Ltd., as a professional manufacturer and wholesaler of Sibutramine hcl 20mg base powder, is committed to providing you with high-purity slimming powder raw materials. In a fiercely competitive market, we have won widespread acclaim for our excellent products and services.
Our advantages are reflected in multiple aspects: modern factory facilities, strict quality control system, sufficient inventory, and highly competitive pricing strategy, which together constitute our solid market position.
Our Factory
We have advanced research and development technology and equipment
Sibutramine hcl 20mg base powder Application
Sibutramine hydrochloride monohydrate was used as standard to screen dietary supplements for sibutramine using ion mobility spectrometer.
Sibutramine powder, as an efficient slimming ingredient, exhibits outstanding efficacy in the field of weight loss due to its unique molecular structure.
The function of this product is not limited to weight loss, but also plays a significant role in regulating metabolism and improving physical fitness, making it a leader among many health products.
Widely used in various fields such as medicine, health products, beauty, etc., sibutramine powder has won wide recognition in the market for its multifunctionality.
Biochem/physiol Actions
Sibutramine hcl 20mg base powder is a serotonin and noradrenaline reuptake inhibitor (SNRI).
Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNRI). It is an antiobesity drug, which decreases calorie intake and increases energy expanditure. Sibutramine antagonizes MPTP-induced dopamine depletion in mouse brain.
How fast does sibutramine powder work?
Sibutramine hcl 20mg base powder is metabolized by cytochrome P450 isozyme CYP3A4 into two pharmacologically active primary and secondary amines (called active metabolites 1 and 2) with half-lives of 14 and 16 hours, respectively. Peak plasma concentrations of active metabolites 1 and 2 are reached after three to four hours.
What is the drug sibutramine used for?
Sibutramine is used together with diet and exercise to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure. Sibutramine may also be used for other purposes not listed in this medication guide.
Is sibutramine effective for weight loss?
Sibutramine therapy also has an effect on the long-term results, with a 10–30% increase in the number of persons who successfully maintain their body weight reduction ('successful' means the maintenance of 80–100% of lost weight)
Effective slimming effect
How to use sibutramine for weight loss?
Sibutramine is taken once daily, generally in the morning. Therapy usually is started with one 20mg tablet per day. The dose may be increased to 25mg by the physician after several weeks to achieve the desired effect.
What is another name for sibutramine?
Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity.
Is Sibutramine hcl 20mg base powder addictive?
Together with the relatively late Tmax of the active metabolites (3-4 hours), this short-term, single-dose study provides strong evidence that sibutramine does not have the potential for abuse that is characteristic of amphetamines and that it is indistinguishable from placebo in abuse potential.
Sibutramine is a serotonin and norepinephrine reuptake inhibitor that has shown efficacy as a weight loss and weight maintenance agent. Because of the abuse liability and physical dependence potential of amphetamines and related antiobesity agents, this study evaluated the abuse potential of sibutramine and compared it with that of dextroamphetamine and placebo in recreational stimulant users. Thirty-one male recreational stimulant users participated in this single-site, Latin square crossover study that compared the effects of two doses of sibutramine (20 mg and 30 mg) to dextroamphetamine (20 mg and 30 mg) and placebo, using a series of validated subjective scales or questionnaires. For scales measuring stimulation and euphoria, there was a greater mean response for dextroamphetamine 30 mg versus 20 mg, with both doses having a significantly greater stimulant and euphoric effect than placebo at the majority of time points (p < 0.05); responses for both doses of sibutramine were statistically indistinguishable from placebo at all time points. Responses to "street value" and "most enjoyed study session" questions confirmed that sibutramine lacks abuse potential; mean cash value estimates of street value were significantly greater for both dextroamphetamine doses than for placebo or either sibutramine doses (p < 0.05), and the rank order of session enjoyment placed both doses of sibutramine last. Together with the relatively late Tmax of the active metabolites (3-4 hours), this short-term, single-dose study provides strong evidence that sibutramine does not have the potential for abuse that is characteristic of amphetamines and that it is indistinguishable from placebo in abuse potential.
Each batch of sibutramine powder comes with a detailed COA (Certificate of Analysis) to ensure the purity and safety of the product, allowing every customer to use it with peace of mind.
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Sr. No.
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TEST
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SPECIFICATION
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RESULT
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1.
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Appearance
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White or almost white,crystalline powder.
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White crystalline powder
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2.
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Solubility
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Practically insoluble in water,sparingly soluble in methylene chloride,slightly soluble in ethanol(96%)and in methanol.It shows polymorphism.
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Complies
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3.
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Identification
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A)By Melting point
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169℃ to 174℃
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171.6℃
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B)By UV
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Specific absorbance at the absorption Maxima: -at 300 nm;61 to 65
-at 275 nm;27 to 32
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Complies
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C)By IR
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The infrared absorption spectrum of the substance being examined in mulls should be concordant with the spectrum obtained from Glibenclamide WRS/CRS
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Complies
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D)By TLC
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The principal spot in the chromatogram obtained with the test solution is similar in position and size to the principal spot in the chromatogram obtained with the reference solution.
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Complies
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E)By chemical test
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The solution is colourless and shows blue fluorescence in ultraviolet light at 365 nm in sulphuric acid.After 5 minutes, colour changes to deep yellow
and,after about 20 minutes develops a brownish tinge with chloral hydrate.
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Complies
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4.
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Related substances(By HPLC)
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Impurity-A
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Not more than 0.30%
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0.05%
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Impurity-C
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Not more than 0.15%
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Not detected
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Unspecified impurity
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Not more than 0.10%
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0.06%
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Total impurities
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Not more than 0.80%
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0.21%
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5.
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Loss on drying
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Maximum 1.00%w/w
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0.17%
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6.
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Sulfated ash
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Maximum 0.10%w/w
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0.06%
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| 7. | Assay (By potentiometry) | 99.0 %w/w to 101.0%w/w(dried substance) | 99.53% |
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Additional test
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8.
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Residual solvents(By HSGC)
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Methanol
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Not more than 3000 ppm
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307 ppm
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Acetone
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Not more than 5000 ppm
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10 ppm
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Methylene chloride
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Not more than 600 ppm
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I ppm
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Ethyl éne chloride
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Not more than 5 ppm
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Not detected
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Toluene
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Not more than 890 ppm
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3 ppm
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The product comply as per above specification.
We have a mature and complete process flow chart, from raw material procurement to finished product delivery, every step is finely managed to ensure the stability of product quality.
Strictly following international quality standards, our sibutramine powder meets or exceeds industry standards in all indicators, ensuring excellent quality for every batch of products.
Relying on advanced production equipment and exquisite production technology, our factory enjoys a high reputation in the industry and has significant technological advantages.
Many cooperative clients have given high praise to our products and company, which is not only a recognition of our work, but also a driving force for us to keep moving forward.
At major industry exhibitions, Guangzhou Jianbei Biotechnology Co., Ltd. has won numerous awards and become the focus of attention in the industry with its high-quality products and professional services.
Packaging and Shipping
1. Packaging specifications
The standard packaging options include aluminum foil bags and transparent food bags for 10 grams, 1 kilogram, 5 kilograms, 10 kilograms, and 25 kilograms. All products are packaged in cardboard boxes.
2. Transportation mode
Domestic orders default to using express delivery services, with an estimated delivery time of 3 to 5 days. Bulk orders are delivered through Debon Logistics and enjoy free shipping services. For cross-border transportation, we offer options for sea freight (expected to arrive in 45 days) and air freight (expected to arrive in 7 days), and will provide necessary customs clearance documents.
Why choose us
Provide comprehensive pre-sales and after-sales services, including product consultation, technical support, logistics tracking, etc., to ensure that customers have no worries during the cooperation process. At the same time, we can also provide packaging and transportation solutions for Sibutramine hcl 20mg base powder according to customer needs, to meet the differentiated needs of different markets
Core values: Direct supply from the source factory+controllable quality+flexible customization, helping customers enter the slimming market with low risk and high profit.
Collaboration support:
Contact Information
Business Manager: Manager Li WATHSAPP+85362906527
Email: h33727868@gmail.com
Factory Address: No. 142 Wushan Road, Tianhe District, Guangzhou, Guangdong Province, China
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