CHina Sibutramine powder

CHina Sibutramine powder in market competition

With the development of the industry, more companies may enter the market for CHina Sibutramine powder, and competition will become increasingly fierce. Guangzhou Jianbei Biotechnology Co., Ltd. needs to continuously optimize its inventory management system and pricing strategy to maintain its market advantage. An efficient inventory management system can ensure timely supply of products, while competitive pricing and market positioning strategies can help attract more customers.
In addition, industry exhibitions are also important platforms for showcasing brand influence and understanding market trends. The excellent performance of Guangzhou Jianbei Biotechnology Co., Ltd. in industry exhibitions not only enhances brand awareness, but also enables timely market feedback, providing reference for product development and market promotion. By analyzing market trends and industry dynamics, combined with its own advantages and characteristics, the company is expected to achieve better development in the future market.

The weight loss principle of CHina Sibutramine powder

Sibutramine hydrochloride monohydrate is a white to cream crystalline powder with a solubility of 2.9 mg/mL in pH 5.2 water. Its octanol: water partition coefficient is 30.9 at pH 5.0. Each MERIDIA capsule contains 5 mg, 10 mg, and 15 mg of sibutramine hydrochloride monohydrate. It also contains as inactive ingredients: lactose monohydrate, NF; microcrystalline cellulose, NF; colloidal silicon dioxide, NF; and magnesium stearate, NF in a hard-gelatin capsule [which contains titanium dioxide, USP; gelatin; FD&C Blue No. 2 (5- and 10-mg capsules only); D&C Yellow No. 10 (5- and 15-mg capsules only), and other inactive ingredients].

Mode of Action Sibutramine produces its therapeutic effects by norepinephrine, serotonin and dopamine reuptake inhibition. Sibutramine and its major pharmacologically active metabolites (M1 and M2) do not act via release of monoamines. Pharmacodynamics Sibutramine exerts its pharmacological actions predominantly via its secondary (M1) and primary (M2) amine metabolites. The parent compound, sibutramine, is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine reuptake in vivo, but not in vitro. However, metabolites M1 and M2 inhibit the reuptake of these neurotransmitters both in vitro and in vivo. In human brain tissue, M1 and M2 also inhibit dopamine reuptake in vitro, but with ~3-fold lower potency than for the reuptake inhibition of serotonin or norepinephrine.

Quality control and detailed testing reports

In order to ensure that product quality meets international standards, Guangzhou Jianbei Biotechnology Co., Ltd. actively obtains international certifications. These international certifications are a high recognition of the company's product quality and management system. For example, the company has obtained ISO9001 quality management system certification, which indicates that the company has reached an international advanced level in quality management. ISO9001 certification requires enterprises to establish a comprehensive quality management system, with strict quality control throughout the entire process from product design, production, sales to after-sales service. By obtaining this certification, Guangzhou Jianbei Biotechnology Co., Ltd. has demonstrated to customers and the market the reliability and stability of its product quality.
COA (Certificate of Analysis) also plays an important role in the quality assurance of sibutramine powder. Each batch of sibutramine powder will be accompanied by a detailed COA report, which includes various quality indicators and test results of the product. These indicators cover multiple aspects of product purity, impurity content, moisture content, and more. For example, the COA report will clearly indicate specific data such as the purity of sibutramine powder being 99.5% and impurity content being less than 0.1%. These data are a visual reflection of product quality, and customers can understand the quality status of the product by viewing the COA report. As the quality management master Dai Ming once said, "Quality is the most economical way to manufacture the most useful products on the market." Guangzhou Jianbei Biotechnology Co., Ltd. provides customers with high-quality and reliable Xibuquming powder products through strict quality control and detailed testing reports.

COA

Main functions and mechanisms of action

CHina Sibutramine powder and its metabolites (M1 and M2) are not serotonin, norepinephrine or dopamine releasing agents. Following chronic administration of sibutramine to rats, no depletion of brain monoamines has been observed. Sibutramine, M1 and M2 exhibit no evidence of anticholinergic or antihistaminergic actions. In addition, receptor binding profiles show that sibutramine, M1 and M2 have low affinity for serotonin (5-HT1, 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C), norepinephrine (β, β1, β3, α1 and α2), dopamine (D1 and D2), benzodiazepine, and glutamate (NMDA) receptors. These compounds also lack monoamine oxidase inhibitory activity in vitro and in vivo.

Absorption Sibutramine is rapidly absorbed from the GI tract (Tmax of 1.2 hours) following oral administration and undergoes extensive firstpass metabolism in the liver (oral clearance of 1750 L/h and half-life of 1.1 h) to form the pharmacologically active mono- and didesmethyl metabolites M1 and M2. Peak plasma concentrations of M1 and M2 are reached within 3 to 4 hours. On the basis of mass balance studies, on average, at least 77% of a single oral dose of sibutramine is absorbed. The absolute bioavailability of sibutramine has not been determined. Distribution Radiolabeled studies in animals indicated rapid and extensive distribution into tissues: highest concentrations of radiolabeled material were found in the eliminating organs, liver and kidney. In vitro, sibutramine, M1 and M2 are extensively bound (97%, 94% and 94%, respectively) to human plasma proteins at plasma concentrations seen following therapeutic doses. Metabolism Sibutramine is metabolized in the liver principally by the cytochrome P450 (3A4) isoenzyme, to desmethyl metabolites, M1 and M2. These active metabolites are further metabolized by hydroxylation and conjugation to pharmacologically inactive metabolites, M5 and M6. Following oral administration of radiolabeled sibutramine, essentially all of the peak radiolabeled material in plasma was accounted for by unchanged sibutramine (3%), M1 (6%), M2 (12%), M5 (52%), and M6 (27%). M1 and M2 plasma concentrations reached steady-state within four days of dosing and were approximately two-fold higher than following a single dose. The elimination half-lives of M1 and M2, 14 and 16 hours, respectively, were unchanged following repeated dosing. Excretion Approximately 85% (range 68-95%) of a single orally administered radiolabeled dose was excreted in urine and feces over a 15-day collection period with the majority of the dose (77%) excreted in the urine. Major metabolites in urine were M5 and M6; unchanged sibutramine, M1, and M2 were not detected. The primary route of excretion for M1 and M2 is hepatic metabolism and for M5 and M6 is renal excretion.

Recognition and evaluation of products by cooperative customers

In the market of CHina Sibutramine powder, Guangzhou Jianbei Biotechnology Co., Ltd. has won high recognition and positive evaluation from cooperative customers with its excellent product quality and service. From the perspective of market position, Guangzhou Jianbei Biotechnology Co., Ltd., as a manufacturer and wholesaler of sibutramine powder, occupies an important position in the industry. The sibutramine powder produced by it has been widely used in multiple fields, as evidenced by feedback from cooperative customers.
The company has significant advantages in production. In the production of high-purity slimming powder raw materials, advanced production technology and strict quality control processes ensure the high quality of the products. According to feedback from cooperative customers, the use of the company's sibutramine powder has improved the product's effectiveness by 30%, which fully demonstrates the advantages of its product. The scale of the factory and advanced production technology enable the company to meet large-scale market demand. According to statistics, the company's monthly output can reach several tons, providing a stable source of goods for many cooperative customers.

Packaging and Shipping

1. Packaging specifications
The standard packaging options include aluminum foil bags and transparent food bags for 10 grams, 1 kilogram, 5 kilograms, 10 kilograms, and 25 kilograms. All products are packaged in cardboard boxes.
2. Transportation mode
Domestic orders default to using express delivery services, with an estimated delivery time of 3 to 5 days. Bulk orders are delivered through Debon Logistics and enjoy free shipping services. For cross-border transportation, we offer options for sea freight (expected to arrive in 45 days) and air freight (expected to arrive in 7 days), and will provide necessary customs clearance documents.

Why choose us

Provide comprehensive pre-sales and after-sales services, including product consultation, technical support, logistics tracking, etc., to ensure that customers have no worries during the cooperation process. At the same time, we can also provide packaging and transportation solutions for Sibutramine genuine powder according to customer needs, to meet the differentiated needs of different markets

Contact Us

Ready to elevate your products with our premium CHina Sibutramine powder? Contact our expert team at h33727868@gmail.com for personalized assistance and to request a quote. Let's partner for your success!